In vivo imaging of the glutathione pathway in breast cancer
This project aims to identify whether patients can be selected for a certain type of therapy by non-invasively imaging the expression of the glutathione s-transferase enzyme. Another potential application of this project lies in the early detection of treatment response and to monitor this in a non-invasive manner. This is particularly important in breast cancer, since chemotherapy and targeted agents may be used, but can have side effects, and not all patients respond to treatment. Early identification of the molecular signature of a breast cancer may allow selection of a more appropriate treatment, thus improving patient outcome.