Biochemical study of genes relating to familial breast cancer

Start Year: 2012
Finish Year: 2015
Chief Investigator: Dr Andrew Deans
Grant Type: Early Career Fellowship

Early Career Fellowship

Several genes have been shown to cause a familial predisposition to breast cancer when one copy is inherited. These include multiple genes that can also cause the rare disorder Fanconi anaemia, when two copies are inherited. Familial breast cancer predisposition and Fanconi anaemia both result from decreased ability to repair damage to our genetic material, DNA.

By reconstructing this DNA repair signaling mechanism in the test tube, this project aims to understand how familial breast cancer and Fanconi anaemia are linked. This study will determine how it contributes to cancer protection and highlight potential strategies for treatment of breast cancer by specifically targeting this genetic pathway.