Validation of a Novel Target that Inhibits Breast Cancer Metastasis
Finish Year: 2020
Chief Investigator: Dr Christine Chaffer
Metastatic breast cancer is breast cancer that has spread to another part of the body. Most commonly this is the brain, bones, liver or lungs. This migration throughout the body is driven in part by specialised aggressive cell populations. The aggressive cells also contribute to the on-set of disease and to the development of treatment resistance. A method of stopping their activity would be beneficial to all stages of cancer.
NBCF-funded researcher Dr Christine Chaffer is developing new techniques to stop these aggressive cells from spreading. In turn, this will prevent tumour progression, recurrence and metastasis. She has discovered a novel marker, called SULF1, that is essential for cell activity. The marker is significantly increased in these aggressive cell populations. By blocking the SULF1, Dr Chaffer has been able to stop the growth and spread of tumours in experimental models.
This project will expand on her initial findings, by investigating the most effective methods of blocking SULF1. If effective, the approach will provide a new therapeutic strategy to prevent metastasis, slow progression and improve outcomes for those affected by breast cancer.