Investigating the role of microRNAs in breast cancer metastasis and proliferation

Start Year: 2009
Finish Year: 2012
Chief Investigator: Dr Cameron Bracken
Grant Type: Postdoctoral Fellowship
Institution: Institute of Medical and Veterinary Science

Postdoctoral Training Fellowship

Alternative Title: Understanding the movement and proliferation of breast cancer cells

MicroRNAs are small molecules that regulate the activity of multiple genes. A family of miRNAs (called miR-200) turn off in aggressive metastatic breast cancer cells.

This project determines what genes the miR-200 family controls, assesses their influence on breast cancer metastasis and identifies and characterises other miRNAs that control breast cancer proliferation. This is performed in both cancer cell lines, and human breast cancer tissue samples.

These complementary strategies will allow us to better understand important underlying factors that control breast cancer that should be useful, both for cancer diagnosis and to find future targets for treatment.