Investigating the role of microRNAs in breast cancer metastasis and proliferation
Finish Year: 2012
Chief Investigator: Dr Cameron Bracken
Institution: Institute of Medical and Veterinary Science
Postdoctoral Training Fellowship
Alternative Title: Understanding the movement and proliferation of breast cancer cells
MicroRNAs are small molecules that regulate the activity of multiple genes. A family of miRNAs (called miR-200) turn off in aggressive metastatic breast cancer cells.
This project determines what genes the miR-200 family controls, assesses their influence on breast cancer metastasis and identifies and characterises other miRNAs that control breast cancer proliferation. This is performed in both cancer cell lines, and human breast cancer tissue samples.