Methylation in ductal carcinoma in situ (DCIS)

Start Year: 2009
Finish Year: 2012
Chief Investigator: Professor Stephen Fox
Grant Type: Cancer Australia Priority Driven Collaborative Cancer Research Scheme(PdCCRS)
Institution: University of Melbourne

Priority-driven Collaborative Cancer Research Scheme (PdCCRS)

Alternative Title: Predicting the outcome of non-invasive breast cancer

Screening has increased the number of non-invasive breast carcinomas. Currently there is a paradox in that patients with in situ carcinoma are frequently treated more aggressively than invasive cancers by mastectomy.

The features that help treatment decisions are crude. This study examines in situ tumours for changes in gene ‘methylation’. This process determines whether genes are active or not to identify patients for appropriate treatment decisions.

This research is co-funded by NBCF and Cancer Australia.