Methylation in ductal carcinoma in situ (DCIS)
Finish Year: 2012
Chief Investigator: Professor Stephen Fox
Institution: University of Melbourne
Priority-driven Collaborative Cancer Research Scheme (PdCCRS)
Alternative Title: Predicting the outcome of non-invasive breast cancer
Screening has increased the number of non-invasive breast carcinomas. Currently there is a paradox in that patients with in situ carcinoma are frequently treated more aggressively than invasive cancers by mastectomy.
The features that help treatment decisions are crude. This study examines in situ tumours for changes in gene ‘methylation’. This process determines whether genes are active or not to identify patients for appropriate treatment decisions.
This research is co-funded by NBCF and Cancer Australia.