Role of key developmental pathways in breast cancer
Finish Year: 2016
Chief Investigator: Dr Anne Rios
Institution: Walter and Eliza Hall Medical Research Institute
Postdoctoral Training Fellowship
Breast cancer is a very complex disease which may consist of up to 10 different subtypes. It is now recognised that breast cancer arises in stem cells – individual cells in the breast which have the ability to develop into any different cell type – or their progeny (called luminal progenitor cells).
This research will generate new mouse models in which certain molecular pathways are overactivated to test their potential to generate subtypes of human breast cancer.
The research will visualise breast cells in their normal tissue environment to better understand how breast tumour cells are able to escape from normal cellular control, invade into nearby tissue and then spread throughout the body.
This research is co-funded by NBCF and Cure Cancer Australia Foundation.