The identification of genes important for lymphatic vascular remodelling during mammary gland development
Finish Year: 2011
Chief Investigator: Ms Kelly Betterman
Institution: University of Adelaide
Doctoral Research Scholarship
Alternative Title: Understanding genes important for the growth and remodelling of lymphatic vessels in the mammary gland
This study looked at identifying genes important for lymphatic vascular remodelling during mammary gland development. Lymphatic vessels are a critical route of transport for tumour cell metastasis. The stimulation of lymphatic vascular growth is one mechanism used by breast tumours to access the lymphatic vascular network and thereby spread to distant sites.
Very little is currently understood regarding the identity of signals that regulate the growth, development and regression of the lymphatic vasculature, processes that normally occur in a highly regulated fashion during breast development.