Selective targeting of breast tumours for boron neutron capture therapy

Start Year: 2008
Finish Year: 2010
Chief Investigator: Associate Professor Louis Rendina
Grant Type: Novel Concept Awards
Institution: University of Sydney

Alternative Title: Targetting breast tumours with a new class of agents for Boron Neutron Capture Therapy

Boron Neutron Capture Therapy (BNCT) is an experimental cancer treatment that utilises a combination of boron-containing agents and neutrons to destroy cancer cells. Unprecedented results from Associate Professor Rendina’s laboratory demonstrate that certain boron-rich agents known as phosphonium salts have the potential to target tumour cells and thereby, significantly enhance tumour selectivity.

For the first time, Associate Professor Rendina investigates the tumour uptake of these agents in human breast tumours which have been implanted in a rat model. The expected outcomes of the research are the identification of lead compounds for their further development as a new class of BNCT agents for the treatment of breast cancer, a completely new approach in the treatment of this devastating disease.